An Antivirulence approach for preventing Cryptococcus neoformans from crossing the blood-brain barrier via novel natural product inhibitors of a fungal …
PA Aaron, K Vu, A Gelli - MBio, 2020 - Am Soc Microbiol
Cryptococcus neoformans (Cn) is the leading cause of fungal meningitis, a deadly disease
with limited therapeutic options. Dissemination to the central nervous system hinges on the
ability of Cn to breach the blood-brain barrier (BBB) and is considered an attribute of Cn
virulence. Targeting virulence instead of growth for antifungal drug development has not
been fully exploited despite the benefits of this approach. Mpr1 is a secreted fungal
metalloprotease not required for fungal growth, but rather, it functions as a virulence factor …
with limited therapeutic options. Dissemination to the central nervous system hinges on the
ability of Cn to breach the blood-brain barrier (BBB) and is considered an attribute of Cn
virulence. Targeting virulence instead of growth for antifungal drug development has not
been fully exploited despite the benefits of this approach. Mpr1 is a secreted fungal
metalloprotease not required for fungal growth, but rather, it functions as a virulence factor …
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